Traumatic injuries of soft tissues; Muscle Bread of Non-Rheumatic and Rheumatic Origin; Diseases of the musculoskeletal system, including rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, osteoarthritis of the spine and peripheral joints; Rheumatic soft tissue lesions.
Diclofenac in the form of eye drops is introduced before surgery in the conjunctival sac, 1 drop 5 times for 3 hours, immediately after surgery, 3 times 1 drop, then 3-5 times for the required time for treatment.
Diclofenac in these dosage forms should be used with caution for elderly patients (including those receiving diuretics), debilitated patients and patients with low body weight, with peptic ulcer of the stomach and duodenum, Crohn's disease, ulcerative colitis, a history of liver disease, liver porphyria, arterial hypertension, chronic heart failure, a significant decrease in circulating blood volume, bronchial asthma, coronary heart disease, cerebrovascular disease, dyslipidemia / hyp erlipidemia, diabetes mellitus, peripheral artery disease, smoking and alcoholism, chronic renal failure, the presence of Helicobacter pylori infection, severe somatic diseases. Diclofenac with glucocorticosteroids (including prednisone), anticoagulants (including warfarin), antiplatelet agents (including acetylsalicylic acid, clopidogrel), selective serotonin reuptake inhibitors (in particular with citalopram, fluoxetine, paroxetine, sertraline) and with prolonged use of non-steroidal anti-inflammatory drugs.
- Preoperative preparation for cataracts - for inhibition of miosis; postoperative prevention and treatment of inflammatory changes; postoperative prophylaxis of macular edema in patients after cataract removal; for the treatment of inflammatory processes of non-infectious conjunctiva; - for the prevention and treatment of post-traumatic processes on the eyeball, accompanied by inflammatory changes.
Active ingredient: diclofenac sodium. 1 ml contains 1.0 mg diclofenac sodium. Excipients: Benzalkonium chloride, Disodium edetate, Boric acid, Trometamin, Polioxil 35, Oleum Ricini, Water for injections.
The drug is well tolerated when used. Possible negative effects are more often associated with a locally irritating effect, which manifest as burning. Rarely, clouding of the cornea, iritis, blurred vision after instillation. In case of intolerance to the drug, allergic reactions, redness of the eyelids, swelling of the face, increased sensitivity to UV, urticaria, exudative erythema, fever, nausea, accompanied by vomiting.
NSAIDs for topical use in ophthalmology. It has anti-inflammatory, analgesic and antipyretic effects.
Upon instillation of eye drops, sodium diclofenac is absorbed into the systemic circulation. However, the level of the active substance in the blood is significantly lower than the limit..
From the side of the organism of vision: rarely - burning, blurred visual perception (immediately after instillation), clouding of the cornea, iritis.
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Pharmacotherapeutic group Non-steroidal anti-inflammatory drugs. Derivatives of phenylacetic acid. Automatic telephone exchange code M01AV05.
Dosage and administration Dose Diklo-Denk 100 Delay should be included according to the severity of the disease. The recommended daily dose for adults and children over 15 years of age is 100 mg of diclofenac. The same dose is used in relatively mild cases of the disease, as well as for long-term therapy. In cases where the symptoms of the disease are most pronounced at night or in the morning, it is advisable to take tablets at night. Diklo-Denk 100 Delay must be taken with a sufficient amount of liquid (at least 1 glass of water), the tablets should be swallowed whole. The duration of treatment is determined by the doctor.
Composition One tablet contains the active substance - sodium diclofenac - 100 mg, excipients: sucrose, cetyl alcohol, povidone K 30, silicon dioxide colloidal anhydrous, magnesium stearate, film composition: hypromellose (type 2910), polysorbate 80, talc, macrogol 6000 titanium dioxide (E171), iron oxide red (E172).
Description Film-coated tablets, brownish red color, round, biconvex.
Exceeding the dose requires symptomatic treatment. Dizziness, headaches, loss of consciousness, disorientation, myoclonic seizures in children, vomiting, nausea, abdominal pain, odd renal and hepatic functions, gastrointestinal bleeding are possible.
• Rheumatic diseases (rheumatoid arthritis, rheumatism, osteoarthritis), • ankylosing spondylitis, • taste, • dystrophic diseases of the joints, • pain in injuries of the musculoskeletal system and (or) soft tissues, • neuralgia, • myalgia, • primary dysmenorrhea.
Approximately 30% of diclofenac is metabolized. Metabolism products are banned by the intestines. Inactive metabolites obtained by conjugation and hydroxylation by hepatocytes are eliminated by the kidneys. The half-life is 2 hours and does not depend on the functions of the kidneys and liver. Binds to blood proteins 99% of the drug.
Diclofenac reduces inflammation of the eyes that may result from infection, trauma, or surgery; reduces miosis during surgical operations, reduces the synthesis of GHGs and their content in anterior chamber.
To inhibit intraoperative myosis, they are instilled into the conjunctival sac for 2 hours at an interval of 30 minutes (4 times) before surgery..
Side Effects: Upset stomach, nausea, heartburn, diarrhea, constipation, gas, headache, drowsiness, and dizziness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
About 65% of the drug in the form of metabolites is excreted by the kidneys, 1% is excreted unchanged, the remaining part is excreted in the bile as metabolites.